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      1. 當前位置:首頁 > 智慧健康列表 > 認知神經科學與技術 > 詳細信息
        乙肝病毒X 蛋白及其在肝癌免疫治療上應用的研究進展
        來源: | 作者: | 發布時間:2013-11-12 9:17:22

        乙肝病毒X 蛋白及其在肝癌免疫治療上應用的研究進展
        岳丹,程平
        基金項目:高等學校博士學科點專項科研基金(20110181120086)
        作者簡介:岳丹(1989 年-)女,碩士研究生,腫瘤分子生物學
        通信聯系人:程平(1980 年-)男,副研究員,腫瘤免疫.

         (四川大學華西醫學中心生物治療國家重點實驗室,成都,610041)
        摘要:肝癌是最常見的惡性腫瘤之一,惡性程度高,病情發展快,病死率極高。目前基于手術、放療、化療的治療手段已取得較大進展,但是治療效果差。HBx 是乙肝病毒X 基因的表達產物,其上存在細胞毒性T 淋巴細胞抗原表位,因此可以成為肝癌治療的一個有效靶點。基于HBx 蛋白或HBx 的抗原表位設計的疫苗可以成為肝癌治療的新型藥物。本文結合HBx 的生物學功能,對HBx 在肝癌免疫治療上的研究進展進行綜述。
        關鍵詞:肝癌;HBx;免疫治療;腫瘤疫苗
        中圖分類號:R39217
        Current status and progress of hepatitis B virus X protein in the immunotherapy of hepatocellular carcinoma
        YUE Dan, CHENG Ping
        (State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041)
        Abstract: Hepatocellular carcinoma is one of the most common malignancy, and it has high degree of malignancy, rapid progression and high mortality rate. Recently considerable progress has been made in treatment of surgery, radiotherapy, chemotherapy, but treatment effect is poor.HBx is the espression product of Hepatitis B virus X gene and has cytotoxic T lymphocyte epitopes. Thus it can be an effective target for treatment of hepatocellular carcinoma. Vaccine designed based on HBx and its epitope can become new drug in treatment of hepatocellular 5 carcinoma. This review outlines the progress of HBx in hepatocellular carcinoma immunotherapy based on its biological function.
        Key words: Hepatocellular carcinoma; HBx; Immunotherapy; Tumor vaccine

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