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      1. 當前位置:首頁 > 智慧健康列表 > 研發與技術創新 > 詳細信息
        STAT家族蛋白的乙酰化修飾與功能調控
        來源: | 作者: | 發布時間:2013-11-12 17:24:43

        STAT家族蛋白的乙酰化修飾與功能調控
        劉鴻,王廷揚,陳月霞,齊宏妍,邵吉民
        基金項目:國家教育部高等學校博士學科點專項科研基金(No.J20100041)和浙江省自然科學基金(No.LY13H160001)資助 作者簡介:劉鴻(1984-),男,博士研究生,主要研究方向:腫瘤病理生理學 通信聯系人:邵吉民(1962-),男,教授,博士生導師,主要研究方向:腫瘤病理生理學.

        (浙江大學醫學院病理學與病理生理學系,杭州 310058)

        摘要:STAT (signal transducer and activator of transcription)蛋白家族是一類具有重要生物學效應的轉錄因子,它們可以被多種細胞因子所激活,并且受到翻譯后修飾(posttranslational modification, PTM)的調控。除酪氨酸和絲氨酸磷酸化以外,近來的一些研究表明賴氨酸乙酰化對STAT信號活性也起到了關鍵的調控作用,多種不同的翻譯后修飾就像組蛋白密碼一樣共同決定著STAT蛋白的功能。本文就STAT家族蛋白的乙酰化修飾及其在細胞因子應答和10 生理及病理生理進程中的作用做一綜述。
        關鍵詞:病理學與病理生理學;STAT;乙酰化修飾;信號轉導;轉錄調節;生物學效應
        中圖分類號:R363.2+1
        Functional role of acetylation in STAT regulation
        Liu Hong, Wang Tingyang, Chen Yuexia, Qi Hongyan, Shao Jimin
        (Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058)
        Abstract: STATs (signal transducers and activators of transcription) belong to a family of transcription factors with diverse biological functions. Their signaling activities are modulated by posttranslational  modifications (PTMs) in response to various cytokines. Besides phosphorylation of tyrosine and serine, lysine acetylation has been recently shown critical in the regulation of STAT functions, while different PTMs serve as a “histone code”-like role to determine the ultimate cellular effects. The physiological and pathophysiological roles of acetylated STATs in mediating cytokine signaling were reviewed here.
        Key words: pathology and pathophysiology; STAT;acetylation;signal transduction;transcriptional  regulation;biological effects

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