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      小鼠膀胱癌原位瘤動物模型建立方法的研究進展
      來源: | 作者: | 發布時間:2013-11-8 16:16:33

      小鼠膀胱癌原位瘤動物模型建立方法的研究進展
      宋玲玲1,2,金巡2,張佩蘭2,程舟禮2,程浩2,茍馬玲1,2
      作者簡介:宋玲玲,1988,女,研究生,腫瘤學
      通信聯系人:茍馬玲,1985,男,副研究員,腫瘤生物治療基礎研究. 

       (1. 四川大學華西醫院腫瘤中心;2. 四川大學生物治療國家重點實驗室,成都,610041)
      摘要:動物模型是研究疾病發生、發展機理與臨床前藥效評價的重要工具。膀胱癌是最常見的泌尿系統惡性腫瘤,急需發展新的治療手段,建立原位膀胱癌模型對研究新型膀胱癌治療手段非常重要。小鼠原位膀胱癌模型是常用的膀胱癌模型,目前的建立方法主要分為誘導法和移植法兩大類,本文將綜述小鼠原位膀胱癌模型的建立方法。
      關鍵詞:原位膀胱癌;動物模型;小鼠
      中圖分類號:R737.14
      Advance of methods to set orthotopic bladder cancer model in mice
      SONG Lingling1, JIN Xun2, ZHANG Peilan2, CHENG Zhouli2, CHENG Hao2, GOU Maling1
      (1. State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,West China Medical School,Sichuan University,Chengdu 610041;2. State Key Laboratory of Biotherapy,Sichuan University,Chengdu 610041)
      Abstract: Animal models are important means for studding the mechanism of diseases occurrence, disease development, and evaluating the potency of drug candidate in preclinical.Bladder cancer is the most common malignant tumor of urinary system, and new methods for bladder cancer therapy are requested. It is of great importance to set orthotopic bladder cancer model for new bladder cancer treatment. Setting orthotopic bladder cancer in mice has the certain difficulty. There are two major methods, derivative method and transfer technique. This article will summarize the methods to set orthotopic bladder cancer model.

      Key words: orthotopic bladder cancer; animal model; mice

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